Effects of plication procedures in special cases of Peyronie's disease: a single-center retrospective study of 72 patients / 亚洲男科学杂志(英文版)

General recommendations regarding surgical techniques are not always appropriate for all Peyronie's disease (PD) patients. Therefore, the purpose of this study was to investigate the effects of plication procedures in PD patients with severe penile curvature and the effects of early surgical correction in patients who no longer have progressive deformities. The clinical data from 72 patients who underwent plication procedures were analyzed in this study. Patients were divided into Groups A and B according to the curvature severity (≤60° or >60°) and Groups 1 and 2 according to the duration of disease stabilization (≥3 months or <3 months). At the 1-year follow-up, 90.0% (36/40) and 90.6% (29/32) patients reported complete penile straightening, and 60.0% (24/40) and 100.0% (32/32) patients reported penile shortening in Groups A and B, respectively. No curvature recurrence occurred in any patient, and no significant differences were observed in postoperative International Index of Erectile Function-Erectile Function domain (IIEF-EF), erectile pain, sensitivity, or suture knots on the penis whether such outcomes were grouped according to the curvature severity or the duration of stabilization. However, the duration from symptom onset to surgical management in Group 1 was significantly longer than that in Group 2 (mean ± standard deviation [s.d.]: 20.9 ± 2.0 months and 14.3 ± 1.2 months, respectively, P < 0.001). The present study showed that the plication procedures seemed to be an effective choice for the surgical treatment of PD patients with severe penile curvature. In addition, the early surgical treatment seemed to benefit those patients who already had no erectile pain and no longer exhibited progressive deformity.

Stem cells for the treatment of Peyronie's disease / 中华男科学杂志

Peyronie's disease (PD) is a connective tissue disorder characterized as fibrotic plaque localized in the tunica albuginea (TA), and its pathomechanism remains obscure. Endeavors are being made to explore effective and minimally invasive therapeutic strategies for PD, and some experimental studies have verified the preventative and therapeutic effects of stem cells (SC), especially adipose tissue-derived SCs (ADSC), on this disease and excavated some of their action mechanisms. Some scholars attempted the integration of SCs with graft tissues, aiming at the improvement of TA grafting and reconstruction. The only publicly available clinical trial of SC therapy for PD was encouraging, and further on-coming relevant researches are expected with simultaneous optimization of the scheme. In a word, the application of SCs in the prevention and treatment of PD is a promising topic for clinical research, and there remain quite a lot of unknowns to be explored. This article summarizes the existing researches in this field.

A new technique, combined plication-incision (CPI), for correction of penile curvature

ABSTRACT Introduction Penile curvature (PC) can be surgically corrected by either corporoplasty or plication techniques. These techniques can be complicated by post-operative: penile shortening, recurrent PC, painful/palpable suture knots and erectile dysfunction. Objective To avoid the complications of corporoplasty and plication techniques using a new technique: combined plication-incision (CPI). Materials and Methods Two groups (1&2) were operated upon: group 1 using CPI and group 2 using the 16-dot technique. In CPI, dots were first marked as in 16 dot technique. In each group of 4 dots the superficial layer of tunica albuginea was transversely incised (3-6mm) at the first and last dots. Ethibond 2/0, passed through the interior edge of the first incision plicating the intermediate 2 dots and passed out of the interior edge of the last incision, was tightened and ligated. Vicryle 4/0, passed through the exterior edges of the incisions, was tightened and ligated to cover the ethibond knot. Results Twelve (57.1 %) participants in group 2 complained of a bothering palpable knot compared to none in group 1 with statistically significant difference (P=0.005). Postoperative shortening (5mm) of erect penis, encountered in 9 participants, was doubled in group 2 but with insignificant difference (P>0.05). Post-operative recurrence of PC, was encountered in only 1 (4.8%) participant in group 2, compared to none in group 1, with insignificant difference (P>0.05). Post-operative erectile rigidity was normally maintained in all participants. Conclusion The new technique was superior to the 16-dot technique for correction of PC.

A wet dressing for male genital surgery: A phase II clinical trial

ABSTRACT Purpose: This study was to confirm the safety and efficacy of BC dressing when used in surgical male wound healing at the urogenital area. Methods: Open, non-controlled clinical study of phase II. A total of 141 patients, among those children, adolescents and adults with hypospadias (112), epispadias (04), phymosis (13) and Peyronie's disease (12) that had a BC dressing applied over the operated area after surgery. A written informed consent was obtained from all participants. Study exclusion criteria were patients with other alternative treatment indications due to the severity, extent of the injury or the underlying disease. The outcomes evaluated were efficacy, safe and complete healing. The costs were discussed. Results: In 68% patients, the BC dressing fell off spontaneously. The BC was removed without complications in 13% of patients at the outpatient clinic during the follow-up visit and 17% not reported the time of removal. In 3% of the cases, the dressing fell off early. Complete healing was observed between 8th and 10th days after surgery. The BC dressings have shown a good tolerance by all the patients and there were no reports of serious adverse events. Conclusion: The bacterial cellulose dressings have shown efficacy, safety and that can be considered as a satisfactory alternative for postoperative wound healing in urogenital area and with low cost.

Application of Human Amniotic Membrane in Canine Penile Tunica Albuginea Defect: First Step toward an Innovating New Method for Treatment of Peyronie?s Disease

Purposes To evaluate the efficacy of human amniotic membrane (AM) grafting in the canine penile tunica albuginea defect; we developed an animal model as the first step toward an innovating new method for the treatment of Peyronie’s disease, penile cancers, and congenital deformities of the penis. Material and Methods From August to September 2011, ten healthy male dogs were selected. A rhomboid incision about 3x2cm over the tunica albuginea and its overlying squamous epithelium was made and then excised. The amniotic membrane was folded twice on itself and grafted on the defect. After 8 weeks, artificial erection was made for 5 dogs and for the other 5 dogs after 12 weeks. After artificial erection, partial penectomy was done and histopathological evaluation was performed on the grafts. Results Artificial erection performed successfully in all of the dogs. No infection or any other complication was seen. Histopathological examination showed complete re-epithelialization with squamous epithelium and collagen fiber deposition. Also, no dysplasia was seen. Conclusions The amniotic membrane can be used as a suitable substitution for tunica albuginea. It is safe, inexpensive, biodegradable, and available and may be used for the treatment of Peyronie’s disease, penile cancers, congenital penile deformities, and penile reconstructive surgery. .

Enfermedad de Peyroni / Disease Peyroni

La enfermedad de Peyroni es un desorden de la ténica albugínea del pene, caracterizado por la formación de placas fibrosas, provocando una curvatura patología del mismo. Este artículo hace una revisión de las opciones terapéuticas y la importancia de un diagnóstico temprano, y de esta manera realizar un adecuado manejo del paciente.

Long-term follow-up of penile curvature correction utilizing autologous albugineal crural graft

PURPOSE: Peyronie's disease is an acquired connective tissue disorder of the penile tunica albuginea with fibrosis and inflammation. The disease produces palpable plaques, penile curvature and pain during erections. Usually it results in impairment of the quality of life. Our objective is to review the long-term results of the albugineal grafting harvested from the penile crura for the treatment of severe penile curvature. MATERIALS AND METHODS: Thirty-three patients with Peyronie's disease were submitted to a grafting with tunica albuginea from the penile crura for the correction of penile curvature. The results were evaluated after 6 months of the procedure. Variables studied were overall satisfaction with the procedure, correction of the penile curvature, erectile capacity, penile shortening and the presence of surgical complications. RESULTS: Mean follow-up after surgery was 41 months. Complete correction of the curvature was achieved in 30 patients (90%). The mean preoperative curvature was 91.8 degrees and median plaque length was 2 cm (ranged from 1 to 5 cm). Three patients (9%) experienced recurrence of the penile curvature and required a new procedure. In 30 men (90%) the procedure fulfilled their expectations and in 31 patients (93.9%) their opinions were that sexual partners were satisfied with the penile correction. Penile shortening or augmentation was referred in 6 (18.1%) and 1 (3%) patient, respectively. CONCLUSION: Our series demonstrated that grafting the albugineal defect after incision of the tunica albuginea with tunica from the crus for the correction of penile curvature is safe and results in satisfactory straight erections duringa long-term follow-up.

Enfermedad de la Peyronie: algunas impresiones sobre la cirugía de la enfermedad avanzada / Peyronie-s disease: some impressions of surgery for the advanced disease

Introducción: La enfermedad de La Peyronie es una entidad relativamente poco frecuente entre la población masculina, pero sus efectos pueden llegar a ser sexual y sicológicamente devastadores para el hombre afectado por ésta. De etiología poco definida, las alternativas terapéuticas son dirigidas solamente a la corrección del defecto. Múltiples técnicas quirúrgicas han sido desarrolladas. Se presenta aquí la experiencia con el uso de vena safena como parche autólogo para cubrir el defecto de la incisión de placa. Material y métodos: Ocho pacientes portadores de enfermedad avanzada, con incurvación y/o deformación incapacitante funcional al pene, son sometidos a esta cirugía. Son evaluados a los tres y cinco meses posoperatoriamente. Resultados: En 4/8 el resultado funcional no es óptimo por la pérdida progresiva de rigidez, lo que obliga a un implante protésico en un segundo tiempo quirúrgico en estos casos para una resolución más definitiva. Conclusión: La edad puede ser un factor pronóstico relacionado y se sugiere para este subgrupo de pacientes considerar el uso conjunto del implante protésico en el primer tiempo, a fin de evitar la necesidad de un segundo tiempo quirúrgico, evitando así la frustración y la incomodidad de volver a ser sometido a una cirugía tanto para el paciente como para el urólogo. No se ha encontrado inconvenientes mayores con el uso de prótesis semirígidas en estos pacientes en su seguimiento a más largo plazo.

Introduction: Peyronie’s disease is a fibrotic disorder with a significant psycologic and physical stress for many men, although the prevalence of the disease has been reported to be low. Up to date the aetiology is unknown, and currently the therapeutic approachremains as a considerable dilemma to practicing physicians. Herein is presented the author’s experience with the use of a saphenous graft to cover a relaxing H-shaped incision of the plaque. Material and methods: 8 patients, with severe disease (curvature or deformity inabiling for a well functioning penis) were surgically treated with thistechnique. They were clinically controlled at 3 and 5 months postoperatively. Results: In 4/8 the final result is not functionally good, at the 5 month control, because ofprogressive lost of erectile rigidity. In this cases a second-time surgery was done for a penile prosthesis implant. Conclussion: Aging could be an important factor related to failure of a one step surgery in this complexed cases using an venous autologous graft.It is suggested to plannify an straigthing venous graft technique with imultaneousprosthesis implant in older men.

Plastia peneana con malla surgisis ® para la corrección de la enfermedad de Peyronie / Correction of Peyronie's disease using surgisis ® mesh

Introducción: La enfermedad de Peyronie (EP) consiste en la formación de una o varias placas fibrosas en el tejido conjuntivo de la albugínea peneana. Esta alteración puede generar una erección curva de grado variable, a menudo dolorosa, ocasionando gran impacto en la calidad de vida. Se reporta una prevalencia entre 3 por ciento a 9 por ciento, pero estudios más recientes la triplican. Se han descrito variados factores de riesgo involucrados, publicándose diversos tratamientos médicos y quirúrgicos, entre los que destacan plicaturas, colocación de prótesis, injertos autólogos, uso de matriz extracelular de tejidos(MECT) o combinación de éstos. Presentamos nuestra experiencia con el uso de MECT de submucosa bovina (Surgisis®) en pacientes portadores de EP, analizando la morbilidad posoperatoria, los resultados estéticos y funcionales en una serie consecutiva de pacientes con seguimiento estricto. Pacientes y método: Desde octubre de 2007 a enero de 2009, 12 pacientes con placas indoloras mayores a 3 cms, medidas por ultrasonografía y curvaturas dorsales mayores a 35°, fueron sometidos, previo consentimiento informado, a una plastia peneana utilizando malla Surgisis®, sin resecar la placa. Todos recibieron 1 gr diario de vitamina E seis meses previos a su intervención. Se excluyeron pacientes con disfunción eréctil severa. Bajo profilaxis con cefazolina, se disecó circunferencialmente hasta la albugínea, liberando el complejo dorsal para identificar y seccionar la placa. El tamaño de la malla fue 30 por ciento mayor al lecho a reparar. Se analizaron atributos personales, resultados quirúrgicos, índice de satisfacción (escala 0 a 10) y seguimiento posintervención (SPSS 15.0, Microsoft®).Resultados: La edad promedio fue de 54 años (45-68). Tiempo promedio quirúrgico: 56 minutos (37-75). El período de hospitalización fue de 1,5 días (1-3). El total de los pacientes de la serie corrigió su curvatura, reportando un índice de satisfacción estético y funcional...

Introduction: Peyronie’s disease (PD) is due to the development of one or several fibrous plaques in the penile albuginia. This alteration may generate an often painful bent erection causing an impact in the quality of life. A prevalence between 3 percent and 9percent has been reported; recent studies triplicate that figure. Different medical and surgical procedures have been described. Among them, plicatures, prosthesis, implants, autologous grafts, use of extracellular tissue matrix (ETM) or a combination of them. We present our experience with ETM from bovine submucosa (Surgisis®) in patients with PD. We described postoperative morbidity, esthetic and functional results in a consecutive series of patients with close follow up. Patients and method: After obtaining informed consent, from October 2007 to January 2009, 12 patients with painless plaques measuring more that 3 cm and dorsal curvature over 35∞, underwent penileplasty with Surgisis® mesh. The plaque was not resected. Before surgery, all patients received 1 gram of Vitamin E daily for six months. Patients with severe erectile disfunction were excluded. During surgery, prophylaxis with Cefazoline was used. A circumferential dissection up to the albuginea was done. The dorsal complex was freed and the plaque was identified and sectioned. The size of the mesh was 30 percent larger than the area to be repaired. We recorded personal data, surgical results, satisfaction index (from 0 to 10) and follow up (SPSS 15.0 Microsoft®).Results: Average age was 54 (45-68). Average surgical time was 56 minutes (37-75). Hospital stay was 1.5 days (1-3). All patients corrected the curvature reporting a satisfaction index over 85 percent. Average follow up was 14 month (7-22). There were no complications. Conclusion: The use of bovine submucosa appears as an excellent procedure for the treatment of PD. The technique is simple and effective with low morbidity, good tolerance and safety.

Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease

OBJECTIVE: Report the results using porcine small intestinal submucosa (SIS) as a graft material in the surgical management of Peyronie's disease (PD). MATERIALS AND METHODS: We performed a retrospective chart review of men with PD who underwent surgical correction of the curvature by plaque “H” incision and patch grafting with 4-ply SIS (Cook, Bloomington, IN) by a single surgeon at our institution. Degree and direction of curvature, sexual function, and co-morbidities were assessed pre- and postoperatively. RESULTS: Thirteen patients were identified. Mean age was 57 ± 8, range 42-70 years. Median follow-up was 14 months, range 3-89 months. At presentation, all reported penile curvature. Also reported were difficulty with vaginal penetration (determined by question number 2 of the sexual encounter profile questionnaire - SEP2), palpable plaque, hourglass deformity, difficulty with firmness, and difficulty with sustaining erection (determined by SEP3) in77 percent, 69 percent, 77 percent, 62 percent, and 46 percent of patients, respectively. Mean and median degrees of curvature of the primary deformity were 71 and 67.5 degrees, respectively. Three patients had secondary curves of less than 30 degrees in a different direction. Mean and median plaque size were 3.5 and 2.7 cm², respectively. Seven patients had one graft and six patients had two grafts placed with a mean size of 15 ± 0 cm². CONCLUSIONS: For the patient with PD, SIS grafting can achieve a functionally straight erection with durable results yet with relatively high rates of erectile dysfunction. SIS is a viable graft material for use in the surgical treatment of PD.

Long-term patient satisfaction after surgical correction of penile curvature via tunical plication

OBJECTIVE: To assess patient satisfaction and functional results at long term follow-up after surgical correction for Peyronie's disease (PD) and congenital penile curvature (CPC) with the technique of tunical plication. MATERIALS AND METHODS: One hundred and two men operated for PD (n = 76) or CPC (n = 26) in four different departments of urology in public hospitals agreed to answer a six-question telephone questionnaire about treatment satisfaction. Tunica albuginea plication procedures represented the standard surgical approach. Subjects under investigation were correction of the deformity, feeling of bumps under the skin, pain during erection, penile sensory changes, development of erectile dysfunction (ED) and postoperative ability for complete vaginal intromission. Subjective response rates were compared using the chi square test on the basis of the etiology of the disease (CPC or PD). RESULTS: Significant differences (p < 0.05) between patients with CPC and PD were noticed in the prevalence of postoperative penile deformity, sensory changes, ED and ability to complete vaginal intromission, PD patients always showing a more pessimistic view. No significant differences (p = ns) were detected in terms of unpleasant nodes under the penile skin or pain during erection. CONCLUSIONS: Long-term outcome after surgical correction for PD and CPC with the technique of tunical plication can be poor. Probably patient expectations are above the real performance of surgical techniques. Preoperative information should be more exhaustive.

Human penile ossification: case report

CONTEXT: Ossification in the human penis is such a rare condition that only 34 histologically evident cases have previously been reported. Among several conditions that have been correlated with this problem the most frequent is Peyronie disease. In all these conditions, human penile ossification appears to be a metaplastic bone formation process. CASE REPORT: A 59-year-old white man presented with a one-year history of slight pain upon erection and during intercourse. He also complained of hard plaque near the base of the penis. One year earlier, he had sustained blunt trauma during intercourse. Examination of the penis revealed a fixed firm mass extending over the proximal third of the penile shaft, measuring 3.0 x 3.0 x 2.0 cm and involving the corporal sponge, without surface extension. There was no impotence or other relevant clinical finding. Radiography on the penis revealed irregular calcification in the same position as the palpable mass and in the septum of the proximal inner third of the penis. The importance of this report lies in the extent of the human penile ossification, as demonstrated by the radiological and histological confirmation.

CONTEXTO: Ossificação do pênis humano é uma condição rara e apenas 34 casos histologicamente evidentes foram relatados. Várias condições foram relacionadas com o problema e o mais freqüente foi a Doença de Peyronie. Em todas, as ossificações parecem ser resultado de um processo de metaplasia com formação óssea. RELATO DO CASO: Um homem de 59 anos branco apresentou-se com história de leve dor no pênis durante as ereções há um ano. Ele também referia a presença de uma placa dura na base do pênis, que começou a crescer após um trauma na relação sexual. O exame do pênis revelou tratar-se de uma massa fixa, firme, no terço proximal do pênis de aproximadamente 3.0 x 3.0 x 2.0 cm, sem extensão para a superfície. Não havia impotência ou outra alteração clínica relevante. A radiografia do pênis identificou extensa área calcificada no corpo esponjoso e região do septo, em correspondência à massa palpada. A importância deste relato é a extensão da ossificação de acordo com a radiologia e confirmação histológica.

Resultados quirúrgicos con técnica de Nesbit para pacientes con enfermedad de Peyronie / Surgical results with the technique of Nesbit for the treatment of Peyronie's disease

Introducción: La enfermedad de Peyronie es una patología del tejido conectivo, localizado en la túnica albugínea del pene. Literatura reciente reporta una prevalencia del 3,2 por ciento. Sin embargo, los datos epidemiológicos son erráticos, debido a que el hombre es reticente a consultar por su situación. Se han descrito numerosos factores asociados a esta condición y se han utilizado diversos tratamientos médicos y quirúrgicos en el manejo de esta enfermedad. Se presenta la serie de pacientes operados en nuestro centro. Materiales y Métodos: En un estudio retrospectivo, se evaluó la serie de pacientes con enfermedad de Peyronie intervenidos quirúrgicamente (técnica de Nesbit), desde el año 1990. Resultados: Un total de 21 pacientes fueron operados, todos con técnica de Nesbit. De éstos, se obtuvieron antecedentes clínicos de 18 pacientes y 12 (63 por ciento) tienen seguimiento clínico reciente. La edad promedio de presentación fue 56,2 años (DE 8,6; rango 37-66). De la serie, 5/18 (27 por ciento) pacientes consultaron por incurvación peniana, 3/18 (17 por ciento) por disfunción eréctil, 6/18 (33 por ciento) por dificultad anatómica para lograr el coito y 4/18 (22 por ciento) se presentaron por incurvación asociado a dolor. La mediana de tiempo de seguimiento posterior a la cirugía fue de 54 meses (DE 5,2; rango 5-178). La incurvación más frecuente fue la dorsal, la que se observó en 9/18 (50 por ciento) pacientes, 4/18 (22 por ciento) incurvación ventral, 4/18 (22 por ciento) dorso-lateral y 1/18 (6 por ciento) izquierda. No hay relación entre la dirección y el grado de incurvación con el dolor, imposibilidad de penetración, disfunción eréctil, tiempo operatorio, ni resultados quirúrgicos. No se presentaron complicaciones perioperatorias. De los pacientes consultados, 9/12 (75 por ciento) manifestaron estar satisfechos con la cirugía desde el punto de vista de expectativas sexuales...

Introduction. Peyronie’s disease (PD) is an abnormality in the connective tissue of the tunica albuginea localized in the of the penis. There is a 3,2 percent prevalence reported in the literature, however that is probably and underestimation due to patient’s avoidance to consult for this cause. Several theories have been proposed to explain PD. Therapeutical options, either medical or surgical are also numerous. We present a series of patients operated in our center with the surgical Technique of Nesbit. Methods. Retrospective analysis of surgical results in a series of patients operated with technique of Nesbit for PD, since 1990. Results. A total of 21 patients were operated. Clinical files were reviewed for the analysis. Follow-up was availablein 12 patients. Mean age at diagnosis was 56,2 years (SD 8,6; 37-66). Patients in the series consulted forpenile curvature (3), erectile dysfunction (6), sexual intercourse disturbances (4) and curvature associated with pain (4). Median follow-up was 54 months (SD 5,2; 5-178). Most frequent curvature was dorsal,verified in 9 patients. 4 patients presented ventral curvature, 4 patients dorso-lateral curvature and 1 patient left curvature. There was no relationship between direction and degree of penis curvature, impossibility of sexual intercourse, erectile dysfunction, operative time and surgical results. There were no perioperative complications. 12 patients were interview for the study. Out of these, 9 were satisfied with the procedure, 2 reported no significant changes after surgery and 1 reported to be worse after the operation. Conclusions: a satisfaction of 75 percent was verified in the cohort presented, herein. The technique of Nesbit is a feasible and reproducible procedure for the surgical treatment of PD.

Corporoplasty with saphenous venous patch graft for Peyronie's disease.

A case of Peyronie's disease with butterfly shaped plaques on the ventrolateral aspect of the penis is described. Long saphenous venous patch graft used in the present case gave excellent result as seen in follow-up for eight months.

disfunção erétil / erectile dysfunction

A disfunção erétíl é a persistente incapacidade de se atingir ou manter uma ereção suficiente para uma relação sexual satisfatória. No Brasil, encontrou-se algumgrau de disfunção erátil em 39,8 por cento da população estudada. Até 1996, os tratamentos recomendados para disfunção erétil eram os dispositivos a vácuo, terapia com drogas vasoativas injetáveis e prótese peniana, quando foram publicados os primeiros resultados clínicos do uso de citrato de sildenafil. A introdução do sildenafil no diagnóstico e tratamento da disfunção erétil determinou uma revolução não apenas médica e científica, mas principalmente social e cultural O alto índice de sucesso, com obtenção de ereções fisiológicas, o que era impossível até então, efeitos colaterais discretos e fácil administração fazem do sildenafíi e dos novos ínibidores da fosfodiesterase não só a primeira opção terapêutica da disfunçáo erétil, como toma a sua investigação clinicamente desnecessária. Para a pequena parcela de pacientes que não responde ao sildenafil, à tadalafila ou ao vardenafil, os tratamentos de segunda e terceira linhas são indicados. A auto-injeçáo de drogas vasoativas e o implante de próteses penianas continuam representando terapias de grande sucesso, mas, devido a suas características mais invasivas, devem ser reservadas para pacientes mais graves. Como vimos, o tratamento da disfunção erétil passou a apresentar alto índice de sucesso, com grande conforto e segurança para o paciente, porém a sua cura ainda é bastante difícil. Contudo, num futuro não muito distante, a terapia gêníca será utilizada para vencermos de forma definitiva a disfunção erétil, anulando o seu impacto marcante na qualidade de vida dos nossos pacientes e daqueles com quem se relacionam.

Sección de placa e injertos de vena safena en la enfermedad de la Peyronie / Plaque section and safein vein grafting in the Peyronie´s disease

El objetivo de este trabajo es evaluar los resultados obtenidos con la técnica de sección de placa e injerto de vena safena para el tratamiento de la enfermedad de la Peyronie. Entre los meses de septiembre de 1998 y diciembre de 1999 se trataron 14 pacientes con ésta técnica en el Hospital Italiano de Buenos Aires. La edad de los pacientes varió entre 42 y 73 años (x=59,2). La placa fue dorsal en 11 pacientes (78,6 por ciento) y ventral en 3 (21,4 por ciento). El grado de la curvatura osciló entre 45° y 120° (x=68,7 por ciento). Previo al tratamiento quirúrgico, 8 pacientes (57,1 por ciento) presentaron algún grado de disfunción eréctil, y tres pacientes refirieron acortamiento peneano importante (2 a 4 cms). Todos los pacientes fueron evaluados por medio del interrogatorio y el examen físico. Se les solicitó Rx. peneana con técnica mamográfica, ecografía y autofotografía con vistas dorsal y lateral del pene en erección. La técnica quirúrgica consistió en una minuciosa disección del paquete neurovascular (en los casos de placas dorsales), sección de la placa en forma de ½H¼ con electrobisturí y cobertura del área de defecto con injerto de vena safena. En 3 casos (21,4 por ciento) se debió realizar una pequeña corporoplastia, para corregir una ligera curvatura lateral residual. El tiempo de internación fue menor a 24 horas en el 93 por ciento de los casos y el seguimiento post operatorio varió entre 9 y 23 meses con una media de 11, 4 meses. En 12 casos (85,7 por ciento) se logró la realineación del pene. De los 6 pacientes que tenían potencia conservada en el preoperatorio, uno refirió disfunción eréctil que se manejó satisfactoriamente con Sildenafil. El 57,1 por ciento (8 pacientes) presentó algún grado de disfunción sexual en el preoperatorio y de éstos 5 pacientes (35,7 por ciento) refirieron disminución de la rigidez luego de la cirugía. Los dos pacientes en quienes fracasó esta técnica presentaban placas ventrales. Un 86 por ciento de los pacientes se manifestaron satisfechos luego de la cirugía. Debido a los resultados obtenidos en nuestra serie (alineación del 86 por ciento), ésta técnica es una buena opción terapéutica cuando la curvatura producida por la placa es mayor de 45° o el acortamiento peneano producida por la enfermedad proscribe la realización de una corporoplastia. No aconsejamos su utilización en casos de placas ventrales...

Tratamiento quirúrgico correctivo de la curvatura peneana en la enfermedad de la Pyronie / Corrective surgery of penile curvature in Peyronie's disease

Objetivo: Evaluar los esultados obtenidos en un grupo de pacientes con corvo sexcundario a Induración plástica de Pene (IPP) en los cuales se realizaron procedimientos quirúrgicos correctivos de la curva. Material y Métodos: Fueron intervenidos quirúrgicamente 33 pacientes con curvatura peneana secundaria a IPP. La edad promedio de la población era de 51,3 años, con un seguimiento promedio de 18,3 meses. En el 63,63 por ciento se trató la placa de fibrosis (PF) con sección o resección, empleándose para la síntesis del defecto creado injerto dérmico, colgajo despitelizado de prepucio o vena safena. En el 36,36 por ciento restante se utilizaron plicaturas peneanas según técnica de yachia o Nesbit. Los pacientes fueron evaluados preoperatoriamente con monitoreo de erecciones nocturnas, test con drogas vasoactivas y documentación fotográfica de la curva; 6 pacientes presentaban disfunción sexual eréctil (DSE) preoperatoriamente. Resultados: El 94 por ciento de los pacientes evolucionaron favorablemente ( sin curva invalidante, potencia y sensibilidad cutánea conservadas). Se observaron complicaciones menopres en el 21,21 por ciento; un paciente presentó DSE postoperatoria y otro hipoestesia glandelar definitiva. No se registraron casos de recidiva orecurrencia. Conclusión: Las técnicas descriptas son efectivas en la corrección de la curvatura peneana secundaria a enfermedad de la Peyronie. Los resultados obtenidos con el empleo de la técnicas descriptas se encuentran dentro de lo observado en la literatura revisada. La objetivación de la potencia preoperatoria, el empleo de una técnica prolija en el traslado de los tejidos y en la disección del paquete vasculonerviosos dorsal son fundamentales para la obtención de resultados adecuados